ACE-031 (1mg)

ACE-031 is a soluble fusion protein consisting of the extracellular domain of activin receptor type IIB (ACVR2B) linked to a human IgG1 Fc region. By acting as a decoy receptor, it sequesters multiple TGF-β superfamily ligands — including myostatin, activin A, GDF-11, and BMP-9 — that negatively regulate skeletal muscle mass.

Research Applications:

• Myostatin and activin signaling pathway studies
• Skeletal muscle hypertrophy and atrophy models
• Muscle wasting disease research (cachexia, sarcopenia, DMD)
• Bone and fat tissue regulation via ACVR2B pathway

Key Properties:
Structure: ACVR2B extracellular domain – IgG1 Fc fusion
Molecular Weight: ~60 kDa
Target Ligands: Myostatin, Activin A, GDF-11, BMP-9

Product Specifications:
Purity: ≥98% (HPLC)
Form: Lyophilized Powder
Storage: −20 °C, protected from light

For research use only. Not for human consumption. Not for veterinary use. No medical or therapeutic claims are made. These statements have not been evaluated by the FDA.