5-amino-1mq

5-Amino-1-methylquinolinium (5-Amino-1MQ) is a small-molecule inhibitor of Nicotinamide N-methyltransferase (NNMT), an enzyme highly expressed in adipose tissue that consumes S-adenosylmethionine (SAM) and shifts cellular methylation capacity away from epigenetic substrates. By inhibiting NNMT, 5-Amino-1MQ is studied for its effects on the SAM/SAH ratio, adipogenesis, and NAD⁺ metabolism.

Research Applications:

• NNMT enzyme kinetics and inhibition studies
• Adipogenesis and fat cell differentiation research
• SAM/SAH methylation ratio and epigenetic regulation
• NAD⁺ biosynthesis and sirtuin pathway research
• Obesity and metabolic syndrome models

Key Properties:
Target: Nicotinamide N-methyltransferase (NNMT)
Molecular Formula: C₁₀H₁₁N₂⁺ (chloride salt)
Molecular Weight: 174.2 Da (free base)
CAS: 1380575-45-0

Product Specifications:
Purity: ≥98% (HPLC)
Form: Lyophilized Powder
Storage: −20 °C, protected from light

For research use only. Not for human consumption. Not for veterinary use. No medical or therapeutic claims are made. These statements have not been evaluated by the FDA.