Survodutide (BI 456906) is a long-acting dual agonist of the glucagon receptor (GCGR) and GLP-1 receptor (GLP-1R). The complementary activation of both receptors drives greater energy expenditure via the glucagon axis while maintaining GLP-1-mediated insulin secretion and appetite regulation.
Research Applications:
- Obesity and energy expenditure research
- Non-alcoholic steatohepatitis (NASH) preclinical studies
- Comparative pharmacology versus GLP-1-only or GCG-only compounds
- Hepatic lipid metabolism investigation
Key Properties:
Receptor Targets: GCGR, GLP-1R
Molecular Weight: ~4,200 Da (acylated peptide)
CAS: 2097131-25-2
Product Specifications:
Purity: ≥98% (HPLC)
Form: Lyophilized Powder
Storage: −20 °C, protected from light
For research use only. Not for human consumption. Not for veterinary use. No medical or therapeutic claims are made. These statements have not been evaluated by the FDA.

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