Semax is a heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) derived from the ACTH(4-7) core sequence with a Pro-Gly-Pro C-terminal extension that enhances CNS penetration and resistance to proteolytic degradation. Originally developed in Russia, it has been studied extensively for its nootropic and neuroprotective properties in preclinical and clinical settings.
Research Applications:
- BDNF and NGF upregulation studies in cortical neurons
- Cognitive function, learning, and memory research
- Stroke and ischemia neuroprotection models
- Dopaminergic and serotonergic system modulation
- HIF-1α pathway and angiogenesis research
Key Properties:
Sequence: Met-Glu-His-Phe-Pro-Gly-Pro
Molecular Formula: C₃₇H₅₁N₉O₁₀S
Molecular Weight: 813.9 Da
CAS: 80714-61-0
Product Specifications:
Purity: ≥98% (HPLC)
Form: Lyophilized Powder
Storage: −20 °C, protected from light
For research use only. Not for human consumption. Not for veterinary use. No medical or therapeutic claims are made. These statements have not been evaluated by the FDA.

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